Ben Greenfield’s Weekly Roundup: April 24

Welcome to Ben Greenfield’s Weekly Roundup!

In this weekly post, I share with you my most interesting discoveries of the week, including the latest news on the fronts of fitness, nutrition, health, wellness, biohacking, and anti-aging research. I also recap my upcoming events and special announcements so you can keep up with opportunities to learn, giveaways, discounts, and more!

New Discoveries

Feel “Weird” During NAD IV Therapy? *These* 3 Tips From a Regenerative Medicine Pioneer Make Your Treatment Smoother, Faster & More Effective ⚡

If you’ve spent any time around longevity clinics, recovery centers, or high-performance circles lately, you’ve probably seen people hooked up to an NAD IV.

NAD (nicotinamide adenine dinucleotide) is one of the most important molecules in the body for turning food into energy and powering cellular repair, which is why these infusions are used to boost energy production, mental clarity, recovery, mitochondrial health, healthy aging, and even resilience after travel, stress, or overtraining.

The thing about NAD infusions is that they can feel intense. Some people experience nausea, flushing, chest pressure, restlessness, or an odd “something feels off” sensation during the drip. It’s why some who try it never go back.

Fortunately, there are ways to make the process much smoother, including these strategies from regenerative medicine pioneer (and this Saturday’s podcast guest), Dr. Joseph Purita.

1. Take TMG Before Your Infusion

TMG (trimethylglycine), also known as betaine, acts as a methyl donor. During NAD infusions, your body produces nicotinamide (NAM), which must be cleared efficiently through methylation by an enzyme called NNMT (nicotinamide N-methyltransferase). This process consumes methyl groups and can temporarily elevate homocysteine, which signals that methylation pathways are becoming depleted, reducing the body’s ability to clear nicotinamide efficiently and contributing to side effects. Taking TMG beforehand may help support methylation pathways and improve tolerance.

2. Sip Coffee During The IV

This one surprises people. The caffeine in coffee can potentially upregulate NMNAT2 (nicotinamide mononucleotide adenylyltransferase 2), a key enzyme involved in recycling NAD precursors back into usable NAD+. Caffeine also blocks adenosine receptors, which may help reduce some of the sluggish or uncomfortable sensations people experience during infusions.

3. Use Red Light To Photoactivate The NAD

Another advanced strategy Dr. Purita uses at PUR-FORM is exposing the NAD solution to red light before it enters the IV bag. This can increase production of NADH, the reduced form of NAD, which can then be rapidly recycled back into NAD+ through mitochondrial complex I to support cellular energy production.

My take is that NAD IVs can be a fantastic tool, but the delivery process makes a big difference in the results.

If you’ve struggled with side effects or want to get more from the experience, these three simple tweaks might make all the difference.

If you want to go deeper on NAD, advanced treatments like IVs, and other regenerative medicine protocols, you can check out the resources below (and don’t forget to tune into Saturday’s show with Dr. Purita by subscribing to my podcast on Spotify, Apple Podcasts, or YouTube):

• Everything You Need To Know About NAD+: The Crucial Role It Plays In Your Mitochondrial Health, How NAD+ Slows Down Aging & Increases Energy, Ways To Increase NAD+ Using Lifestyle, Why NAD+ Precursors May Be Problematic & A Safe, Cost-Effective Oral NAD+ Supplement Strategy.
• The NAD Supersode: All Ben’s Crazy Questions About NAD, Natural Ways To Increase NAD, Living To 120 With NAD & Much More With Matt Titlow & Michael Roberts.
• Could NAD IVs Be Bad For You (& How To Boost NAD Naturally), With Dr. Nichola Conlon.
• The AMAZING Future Of Regenerative Medicine, The New Sexier Alternative To Stem Cells, Where You Should Get Peptides (& The Best Peptides Stacks) & More With Dr. Matt Cook.
• Peptides, Biologics & Small Molecules You’ve *Never Heard Of* For Sleep, Mitochondria, Kidney Health & More, With Jim LaValle.
• Ben Greenfield’s Game-Changing Biohacks & Health Trends of 2025: 10 Science-Backed Strategies For Revolutionizing Human Performance.
• ONE Tiny Blood Spot = HUNDREDS (!) Of Biomarkers, Age & Disease Prediction With Dr. Matt Dawson.

Panicking over what to get Mom this Mother’s Day and have no idea where to start, or just don’t want to give her another *boring* gift this year? 

Skip the usual suspects: flowers that fade within three days, candles that quickly burn out, and bath bombs that stain your bathtub cotton candy blue.

The special woman in your life deserves something incredible that *actually* lasts. I mean, she changed your diapers, right?

So… I put together my 2026 Mother’s Day Gift Guide with one thing in mind: helping you give Mom a vetted present that delivers her fresh energy, better recovery, unparalleled sleep, and long-term health.

🎁 Just a few highlights from the guide:

• Sunlighten mPulse Sauna: Personalized infrared sauna sessions for recovery, relaxation, detox, and deeper sleep.
• Apollo Neuro: A wearable designed to support calm, stress resilience, and better sleep.
• Young Goose Gift Sets: Advanced skincare protocols focused on repair, cellular energy, and skin longevity.
• Pendulum Metabolic Daily: Clinically studied probiotics for gut health, metabolism, and steady energy.
• LIFEprint HTMA Test: At-home testing to expose hidden mineral imbalances, stress patterns, and energy roadblocks.
• Boundless: My bestselling health optimization book packed with strategies for hormones, metabolism, longevity, and peak performance.

So, what are you waiting for?

Scroll through, find Mom a memorable gift, and use the discount codes listed in the guide for extra savings on these time-sensitive deals.

👉 Grab the Perfect Gift for Mom